A $160 million medical research program in NSW could uncover the next big health breakthrough.

Heading into its fourth round, the state’s Medical Research Support Program (MRSP) aims to support excellence in health and medical research by funding the indirect costs of research, such as equipment and support staff.

Applications for the program, which is administered by the Office of Health and Medical Research, are now open.

Previous recipients include the Black Dog Institute, Garvan Institute of Medical Research, Ingham Institute for Applied Medical Research, and the Woolcock Institute.

Funding from previous rounds of the MRSP has aided in the development of Australia's first precision medicine program for children with cancer, development of a single test for over 50 genetic diseases, and personalised digital mental health tools to deliver evidence-based therapies for people living with depression, anxiety and stress.

MRSP Application Guidelines and Program Details can be found at Medical Research Support Program.