Official documents show thousands of highly addictive medicines and drugs have been stolen from Queensland's busiest hospitals.

Documents obtained under Right to Information unaccounted-for medication across the Metro North and Metro South districts around Brisbane includes drugs like Fentanyl, Oxycodone and Methadone.

Thousands of doses are presumed missing or stolen, with some staff facing disciplinary action.

Queensland Health employees are suspected of stealing several medications, including Propofol and diabetic treatment drug Novorapid from the Royal Brisbane and Women's Hospital.

Almost 3,500 vials of the stimulant Ephedrine have gone missing from the Princess Alexandra Hospital in South Brisbane, without an identified reason.

At least one matter has been referred to the Crime and Corruption Commission.

“A detailed investigation was undertaken and as a result, a number of improvements and control measures have been implemented to mitigate drug discrepancies in this area,” a Metro South spokesperson has told reporters.

“This matter is subject to an ongoing confidential disciplinary process.”

A Metro North spokesperson says staff must report discrepancies in missing medications.

“Metro North Hospital and Health Service has robust security measures in place to support patient safety and ethical practice,” the spokesperson said.

“Any instance of suspected-stolen or unaccounted-for medication is investigated at a facility level or by the Metro North Integrity Unit.”

Reports say several Metro North cases are being investigated.